Who is most likely to experience long-term health effects of COVID-19?

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Observational study: A study in which the subject is observed to see if there is a relationship between two or more things (eg: the consumption of diet drinks and obesity). Observational studies cannot prove that one thing causes another, only that they are linked.

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A Swedish study of over 200,000 people who tested positive for SARS-CoV-2 between March 2020 and July 2021 has found that women, people with asthma and those with previous mental health disorders are more likely to experience long-term effects of COVID-19. The proportion receiving a post-COVID-19 condition diagnosis was 1% among individuals not hospitalized for their COVID-19 infection, 6% among hospitalized, and 32% among individuals treated in intensive care units (ICUs). Among individuals with a post-COVID-19 condition, the use of outpatient care was substantially elevated up to one year after the acute infection, the team says.

Journal/conference: Journal of Internal Medicine

Research: Paper

Organisation/s: Karolinska Institutet, Sweden

Funder: The work was supported by grants from EuCARE, Region Stockholm, the Swedish Research Council (Dnr 2021–04809 and 2021–06540), the Swedish Heart and Lung Foundation, and Emil and Wera Cornell Foundation. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Media release

From: Wiley

Are certain patient characteristics linked with long-term health effects of COVID-19?

A recent analysis in the Journal of Internal Medicine has identified several characteristics associated with a higher likelihood of receiving a post COVID-19 condition diagnosis.

In the study of 204,805 individuals who tested positive for Sars-CoV-2 in Stockholm, Sweden from March 2020 through July 2021, the proportion receiving a post COVID-19 condition diagnosis was 1% among individuals not hospitalized for their COVID-19 infection, 6% among hospitalized, and 32% among individuals treated in intensive care units (ICUs). Female sex, previous mental health disorders, and asthma were associated with post COVID-19 condition among non-hospitalized and hospitalized individuals. Among individuals with post COVID-19 condition, use of outpatient care was substantially elevated up to one year after the acute infection.

“In this study, we observed a marked difference in the occurrence of post COVID-19 condition diagnosis across different severities of the acute infection,” said corresponding author Pontus Hedberg, MD and postdoctoral researcher at Karolinska Institutet. “Furthermore, the elevated outpatient primary and specialist care use indicates poor recovery for individuals suffering from post COVID-19 condition, highlighting the urgent need to better understand this condition and its potential resolution over time.”

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