From cancer therapeutics to critical minerals recovery - Building tech to secure the world’s critical metals

Publicly released:
Australia; International; NSW; SA
Schematic representation of peptide-mineral matching
Schematic representation of peptide-mineral matching

Australian Research Council (ARC) funded / ARC Centre for Excellence for Enabling Eco-Efficient Beneficiation of Minerals (COEMinerals) scientists have applied learnings from multiple scientific disciplines to find the one-in-a-billion peptide molecule targeting a given mineral or metal - like a cancer drug targets tumours. This unlocks a radically cleaner, smarter way to recover rare earths and other critical metals. The discovery - to be formally announced on Thursday 31 July at Parliament House in Canberra - could revolutionise mineral processing and boost Australia's sustainability credentials in the global energy transition.

Media release

From: ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals

Researchers at the Australian Research Council (ARC) Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals (COEMinerals) have made a significant breakthrough in the recovery of critical and rare earth minerals and metals, advancing Australia’s sustainability goals and strengthening its strategic industries.

Led by Centre researcher Professor Chun-Xia Zhao from the University of Adelaide’s School of Chemical Engineering, the Centre has applied learnings from multiple scientific disciplines to mimic how a cancer-targeting drug finds cancer cells – but in this case finding a one-in-a-billion peptide molecule targeting a given mineral or metal.

“We knew nature contained molecules with selective binding properties,” said Professor Zhao. “By harnessing these properties, we were able to find precise peptide matches for specific minerals, each one fitting like a jigsaw puzzle.”

This advancement has the potential to unlock the equivalent of a ‘DNA code’ for every mineral and metal on planet Earth and revolutionise mineral processing. It also heralds environmental benefits.

“Current mineral separation processes can require hundreds of stages. This is not only inefficient and costly but involves toxic solvents that harm the environment. In contrast, the Centre’s new biomolecule approach offers selective and recyclable peptides as a single-stage process, reducing both complexity and waste”, Professor Chun-Xia Zhao added.

Published research overviews the biotechnology approach testing on silver, which resulted in selective separation of silver particles from silica, a common waste byproduct, and achieving over 98% silver purity, with a recovery rate of more than 95% (as published in Advanced Functional Materials, DOI: 10.1002/adfm.202504992 - embargoed until 31 July 2025). Broader testing is now underway, with early indications that the peptide-matching approach offers promising performance, especially for rare earth minerals.

ARC Chief Executive Officer Professor Ute Roessner commented: “This achievement shows how government support for research can lead to real-world outcomes that boost innovation, improve productivity, and benefit Australia in the long run”.

Propelling the move from idea to industry impact, a license agreement is in place with Theia Metals Pty. Ltd. to progress the next stage of technology development.

Theia Metals CEO Russell J. Howard, an Australian entrepreneur, scientist and executive who is a pioneer in the field of molecular science, formally based in California shared: “Partnership and licensing to Theia Metals begins the process of investor and corporate mining partner-led development of this technology to the marketplace”.

Multimedia

1:30 (horozontal) short reel with Prof. Chun-Xia Zhao for socials
Interview Prof Chun-XIa Zhao (with audio) + BRoll background in lab (no audio)
Short form video - for socials (less than 2 minutes)

Attachments

Note: Not all attachments are visible to the general public. Research URLs will go live after the embargo ends.

Transcript ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals DOCX , 383.9 KB Interview with Prof. Chun-Xia Zhao
Supplementary Information ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals, Web page The COEMinerals website will have links to add additional materials from 6am, 31 July
Research ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals, Web page Research paper: Advanced Functional Materials - A Sustainable Biotechnology Approach for Mineral Separation - 31 July 2025
Journal/
conference:
Advanced Functional Materials Journal
Research:Paper
Organisation/s: ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals, Australian Research Council (ARC)
Funder: The ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals (COEMinerals) is funded by the Australian Government through the Australian Research Council Centres of Excellence funding scheme.
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