EXPERT REACTION: WHO restarts hydroxychloroquine trials after study data raises concerns
Opinion piece/editorial: This work is based on the opinions of the author(s)/institution.
The WHO has restarted the hydroxychloroquine arms of its trials after earlier suspending them over safety concerns. The news comes as notices of concern are raised by two of the world's leading scientific journals, The Lancet* and NEJM, over data from a company called Surgishere that was used in two studies which suggested hydroxychloroquine was associated with a higher mortality rate in Covid-19 patients and increased heart problems.The governance committees for the AustralaSian COVID-19 Trial (ASCOT) have also unanimously agreed that ASCOT should proceed with randomising patients to the hydroxychloroquine arms of the study. Below, Australian experts comment
UPDATE 5 June 2020: The Lancet have now retracted the paper after three authors "were unable to complete an independent audit of the data underpinning their analysis. As a result, they have concluded that they "can no longer vouch for the veracity of the primary data sources."
Organisation/s: The University of Adelaide, The Australian National University, The University of Sydney, The University of Melbourne, Australian Catholic University
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Expert Reaction
These comments have been collated by the Science Media Centre to provide a variety of expert perspectives on this issue. Feel free to use these quotes in your stories. Views expressed are the personal opinions of the experts named. They do not represent the views of the SMC or any other organisation unless specifically stated.
Associate Professor Steven Tong, is the ASCOT Principal Investigator, and a Royal Melbourne Hospital infectious diseases clinician and co-lead of clinical research at the Doherty Institute