Vitamin C ‘mega-dose’ may do more harm than good for treating septic shock

Publicly released:
Australia; New Zealand; International
Photo by Mufid Majnun on Unsplash
Photo by Mufid Majnun on Unsplash

A 'mega dose' of Vitamin C may be harmful rather than helpful for patients with sepsis who are in the ICU, according to Australian and international research. Previous studies had been mixed as to whether there may be some benefit of giving sepsis patients a high dose of Vitamin C, but many of those studies had been quite small. This new study looked at nearly 900 sepsis patients who were also receiving drugs to increase their blood pressure - a mainstay of sepsis treatment. The study found a higher risk of death or persistent organ dysfunction in patients who received Vitamin C compared to those who received placebo.

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Research Massachusetts Medical Society, Web page Please link to the article in online versions of your report (the URL will go live after the embargo ends).
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conference:
New England Journal of Medicine
Research:Paper
Organisation/s: Monash University, University of Auckland, University of Otago, University of Toronto, Université de Sherbrooke, Canada
Funder: Supported by the Lotte and John Hecht Memorial Foundation. Nova Biomedical Canada provided glucometers, testing strips, and control solutions (StatStrip Express) to trial sites that requested them. Vitamin C that was used at trial sites in Canada and New Zealand was purchased from Mylan.
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