Ozempic-like drugs work best in women

Embargoed until: Publicly released: 2026-03-03 03:00

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An international team of researchers say glucagon-like peptide-1 receptor agonists (GLP-1 RAs) - the type of diabetes/weight loss drugs that include Ozempic and Wegovy - are more effective in women than men. The team reviewed 41 past papers that included 64 clinical trials, and say that while the drugs worked better for weight loss in women, there was no other difference for age, race, ethnicity and starting body mass.

News release

From: JAMA

Heterogeneity of Treatment Effects of GLP-1 RAs for Weight Loss in Adults

About The Study: In this systematic review and meta-analysis, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations. These findings may inform clinical decision-making.

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Journal/
conference: JAMA Internal Medicine

Research:Paper

Organisation/s: Johns Hopkins Bloomberg School of Public Health, USA

Funder: No funding information provided.

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