No heart risks for menopause hormone therapy for hot flashes and night sweats if you are in your 50s

Embargoed until: Publicly released: 2025-09-16 01:00

International

Photo by Chandan Chaurasia on Unsplash

Age is a factor in determining the heart risks linked to hormone therapy for menopausal hot flashes and night sweats, according to a reanalysis of two clinical trials, which found no extra heart disease risks from hormone therapy to treat menopausal hot flashes and night sweats in women aged 50-59. In contrast, the study found increased heart disease risks for women aged 70 years or older. The researchers say the findings support guidelines recommending treatment of hot flashes and night sweats with hormone therapy in women aged 50 to 59 years, caution if initiating hormone therapy in women aged 60 to 69 years, and avoidance of hormone therapy in women 70 years and older.

Attachments

Note: Not all attachments are visible to the general public. Research URLs will go live after the embargo ends.

Research JAMA, Web page Please link to the article in online versions of your report (the URL will go live after the embargo ends).

Editorial / Opinion JAMA, Web page Please link to the article in online versions of your report (the URL will go live after the embargo ends).

Journal/
conference: JAMA Internal Medicine

Research:Paper

Organisation/s: National Heart, Lung, and Blood Institute, USA

Funder: TheWomen’s Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, and US Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. Active and placebo study pills were donated by Wyeth Ayerst.

Media Contact/s

Contact details are only visible to registered journalists.