Moderate to severe MS and pregnancy

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Australia; VIC
Credit: A boy and the sea. E+ via Getty Images
Credit: A boy and the sea. E+ via Getty Images

A Monash University-led study published in JAMA Network Open was the first to examine the impact of pregnancy on multiple sclerosis (MS) relapse activity and long-term disability progression in women with moderate to severe disability. Most previous research has focused on women with mild MS-related disability.

Media release

From: Monash University

A Monash University-led study published in JAMA Network Open was the first to examine the impact of pregnancy on multiple sclerosis (MS) relapse activity and long-term disability progression in women with moderate to severe disability. Most previous research has focused on women with mild MS-related disability.

Similar to findings in women with minimal disability, MS relapse rates decrease during pregnancy and increase in the first three months postpartum in women with more significant MS disability. Pregnancy does not worsen long-term disability outcomes in this population.

Comments attributable to first author Dr Jessica Shipley, Monash Department of Neuroscience, School of Translational Medicine.

“Until now, we have not had an evidence base that we could use to advise women with moderate to severe MS-related disability about the likely impact of pregnancy on their long-term MS outcomes. Our findings provide reassurance that pregnancy does not accelerate long-term disability in women living with more significant MS-related impairment. This research helps inform pregnancy counselling for women with moderate to severe MS-related disability, giving them clearer information to support family planning decisions. By focusing on a group that has been largely understudied, we’re building a more complete understanding of how pregnancy affects MS across the full spectrum of disability.”

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Journal/
conference:
JAMA Network Open
Research:Paper
Organisation/s: Monash University, The University of Sydney, The University of Melbourne, The University of Newcastle, The University of New South Wales
Funder: Dr Shipley reported receiving a Research Training Programstipend scholarship at Monash University from the Australian government during the conduct of the study.Dr Beadnall reported receiving educational travel support from Merck and Novartis and personal fees from Roche,Novartis, and Biogen outside the submittedwork. Dr Yeh reported receiving personal fees from Merck and Novartis; travel support from UCB; and research support from the European Committee for Treatment and Research in Multiple Sclerosis and RACP Foundation outside the submittedwork. Dr Horakova reported receiving grants from First Faculty of Medicine Charles University and General University Hospital in Prague during the conduct of the study and personal fees from Merck, Sanofi, Roche, and Biogen outside the submittedwork. Prof Havrdova reported receiving personal fees from Sanofi AB, Roche, Johnson&Johnson AB, Merck AB, and Novartis outside the submittedwork. Prof Kalincik reported receiving personal fees fromMSInternational Federation andWorld Health Organization, Therapeutic Goods Administration, BMS, Roche, Janssen, Genzyme,Novartis, Merck, and Biogen; conference travel support and/or speaker honoraria fromWebMD Global, Merck, Sandoz, Novartis, Biogen, Roche, Eisai, Genzyme, Teva, and BioCSL; and research or educational event support from Biogen, Novartis, Genzyme, Roche, Celgene, and Merck outside the submittedwork. Dr Roos reported receiving grants from National Health and Medical Research Council (NHMRC) and personal fees from Merck, Novartis, and Roche outside the submittedwork. Prof Lechner-Scott reported receiving grants from Merck, personal fees from Merck, and personal fees from Novartis outside the submittedwork. Dr Alroughani reported receiving personal fees from Roche,Novartis, AstraZeneca, Merck, Biogen, and Sanofi outside the submitted work. Dr Peterka reported receiving personal fees from Merck, Novartis, Biogen, Sanofi-Genzyme, Janssen-Cilag, Teva, Roche, and Bristol-Myers Squibb.Dr Buzzard reported receiving personal fees from Biogen, Roche, Merck, Sanofi, and Novartis during the conduct of the study and personal fees from Alexion, UCB, and Argenx outside the submittedwork. Dr Maimone reported receiving personal fees from Biogen, Merck, Novartis, Roche, Sanofi, and Alexion outside the submittedwork. Dr Foschi reported receiving personal fees from Roche,Novartis, Merck, Sanofi, Biogen, and Bristol-Myers Squibb during the conduct of the study.Dr Lugaresi reported receiving grants from Novartis and Roche and personal fees from Alexion,Amgen/Horizon, Biogen, Bristol-Myers Squibb/Celgene, Merck Serono,Novartis, Roche, Sanofi/Genzyme, and Janssen/Johnson&Johnson outside the submittedwork. Prof Tomassini reported receiving personal fees from Roche,Novartis, Viatris,Amgen, Merck, Bristol-Myers Squibb, Janssen, Alexion, Horizon, and Biogen outside the submittedwork. Dr John reported being a PI onMS commercial studies sponsored by Roche,Novartis, Sanofi-Genzyme, and Biogen and receiving personal fees from Merck and Novartis outside the submittedwork. Dr Meca-Lallana reported receiving personal fees from Almirrall, Biogen, Neuraxpharm, and Sandoz; grants from Biogen and UCB; nonfinancial support, personal fees, and grants from Bristol-Myers Squibb, Merck, Novartis, Roche, and Sanofi; and nonfinancial support and personal fees from Johnson&Johnson outside the submittedwork. Prof Butzkueven reported receiving support to institution from Roche and Merck; service agreement fees to institution from Novartis, Merck, Biogen, and UCB; travel support from Novartis and Merck; and personal fees from Merck, Novartis, and Roche outside the submittedwork. Dr Van derWalt reported receiving personal fees from Novartis, Roche, and Merck; grants, travel support, and personal fees fromMSAustralia; grants from NHMRC; and personal fees as Chief Operating Officer from MSBase Foundation outside the submittedwork. Dr Jokubaitis reported receiving grants from NHMRC,MSAustralia, Australian Medical Research Future Fund, F. Hoffman La-Roche, and Pennycook Foundation and personal fees from Novartis outside the submittedwork. No other disclosures were reported.
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