Induction at 41 weeks almost halves the risk of stillbirth or death in overdue babies
Embargoed until:
Publicly released:
2025-01-17 06:00
Risk of stillbirth or newborn death before 28 days was almost halved in 'overdue' pregnancies lasting beyond 41 weeks, according to international researchers, who found that shifting from induction at 42 weeks to more active management and offering induction at 41 weeks reduced the rates of stillbirth or death before 28 days. The team conducted a nationwide register-based cohort study, looking at over 150,000 deliveries by women with a single overdue pregnancy lasting 41 or more weeks. They found that active management of overdue pregnancies and induction at 41 weeks was associated with a decrease in perinatal deaths of infants and a reduction in severe disease or birth trauma. The team say that women who have pregnancies which are advancing towards 41 gestational weeks should be given balanced information on the benefits and risks of induction of labour at 41 weeks compared to expectant management until 42 weeks, and be offered induction of labour at 41 weeks or active surveillance of pregnancies from 41 weeks in order to decrease peri/neonatal deaths.
Journal/conference: PLOS Medicine
Research: Paper
Organisation/s: University of Lund, Sweden
Funder: This work has been supported by the
Swedish state under the agreement between the
Swedish government and the county councils, the
ALF-agreement (ALFGBG-70940, CB), (ALFGBG-
74830, UBW), (ALFGBG-965174, HH), the Hjalmar
Svensson Foundation (UBW), Swedish state under
the agreement between the Swedish government
and the county councils, the ALF-agreement
(ALFGBG-970689, VS), grants from a regional
agreement on clinical research (ALF) between
Region Stockholm and Karolinska Institutet
(RS2022-0674, MN), and the Childhood
Foundation of the Swedish Order of Freemasons
(MN). The funders had no role in the study design,
data collection and analysis, decision to publish, or
preparation of the manuscript.
Media release
From: PLOS
Peer-reviewed; Observational study; People
Risk of stillbirth and newborn death before 28 days was almost halved in “overdue” pregnancies lasting beyond 41 weeks, in nationwide Swedish study offering active management and induction of labor