What happens when patients try to control who they're getting their blood donation from?

Publicly released:
Australia; International; VIC
Photo by LuAnn Hunt on Unsplash
Photo by LuAnn Hunt on Unsplash

Pushes in several US states to legislate a patient's right to demand a blood donation from a specific donor raise safety and ethical concerns, according to a commentary piece by international and Australian researchers. They say transfusions from directed donors rose by 11.1% between 2019 and 2021, primary because of patients trying to avoid exposure to blood from COVID-19-vaccinated donors. The researchers say there is no evidence to support any safety benefits of directed donations, however there is evidence directed donations have greater safety risks with a higher likelihood of a first-time donor carrying an infectious disease. The researchers say any legislation legitimising this request runs the risk of undermining trust in blood safety protocols, and can be a slippery slope to discriminating against donors for other reasons such as race or sexuality.

Media release

From: American College of Physicians

As demand for “nonvaccinated” blood increases, experts call for national policy prohibiting directed blood donations 
Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-25-00815

According to data from the 2021 U.S. National Blood Collection & Utilization Survey, transfusions from directed donors, or those chosen specifically by the recipient, have increased by 11.1% as compared with 2019. Requests are primarily being driven by recipients’ desire to avoid exposure to blood from COVID-19–vaccinated donors. Now, some states, such as Iowa, Kentucky, and Wyoming, have sought to mandate requests for directed donation, including those demanding “nonvaccinated” blood. The authors of a commentary published in Annals of Internal Medicine say a national policy prohibiting such practices is warranted.  

Lead authors from the University of Minnesota, the Association for the Advancement of Blood and Biotherapies (AABB), Vanderbilt University Medical Center, and Johns Hopkins University say that directed blood donation for nonmedical reasons contradicts ethical imperatives by creating separate access routes influenced by privilege or prejudice. These requests for nonvaccinated blood are driven by misconceptions about vaccine safety. But decades of advancements in donor recruitment and screening have significantly enhanced the safety of the blood supply, refuting this argument. In fact, it's directed donations, rather than anonymous community donations, that may pose accentuated health risks for prospective recipients. For example, first-time parental donors who seek to donate for their children have significantly higher rates of infectious disease marker positivity (8.6%) as compared with first-time community donors (1.09%). In addition, directed donation is resource-intensive, imposing vastly greater operational and logistic complexity than community volunteer blood donation and may contribute to shortages. The authors say that while permitting requests for unvaccinated blood may alleviate psychological distress for some patients and foster trust in medical care, it does not entitle patients or their affiliates to demand medical interventions that lack scientific justification, and physicians are not required to provide nonbeneficial interventions.

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Research American College of Physicians, Web page The URL will go live after the embargo ends
Journal/
conference:
Annals of Internal Medicine
Research:Paper
Organisation/s: Australian Red Cross, The University of Melbourne, Vanderbilt University Medical Center, USA
Funder: Dr. Bloch was supported in part by the National Heart Lung and Blood Institute (1K23HL15182). Dr. Delaney is a member of BLOODSAFE. The BLOODSAFE program is supported by research grants from the National Heart, Lung, and Blood Institute (NHLBI grants UG3HL151595, UG3HL151599, UG3HL152189, and U24HL151541). Dr. Ferguson is one of the theme leads of the NIHR/NJSBT Blood and Transplant Research Units (BTRU) in donor health and behavior, which is funded by the National Institute of Health and Care Research (NIHR) and has several research projects funded by NHS Blood and Transplant (NHSBT). Dr. Ferguson has previously had research funded by Pfizer, Versus Arthritis, and the EU.
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