Single dose of Johnson & Johnson vaccine 73.6% effective against COVID-19

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Photo by Mohammad Shahhosseini on Unsplash
Photo by Mohammad Shahhosseini on Unsplash

A single dose of the Johnson & Johnson (Janssen) vaccine is 73.6 per cent effective at preventing COVID-19 infection, according to a US study. The researchers looked at the health records of nearly 90,000 unvaccinated people and nearly 9000 people vaccinated with J&J from February to July 2021. 0.7 per cent of vaccinated participants tested positive during the study, compared to 2.5 per cent of the unvaccinated participants. The researchers say this shows J&J is still an effective vaccine against variants, with Alpha and later Delta making up the bulk of cases during the study.

Media release

From: JAMA

The findings of this study, which included 8,889 patients who received a single dose of the Ad26.COV2.S (Johnson & Johnson) COVID-19 vaccine and 88,898 unvaccinated patients, are consistent with the clinical trial–reported efficacy of Ad26.COV2.S, suggesting that the vaccine is effective at reducing SARS-CoV-2 infection, even with the spread of variants such as Alpha or Delta that were not present in the original studies, and reaffirm the urgent need to continue mass vaccination efforts globally.

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Organisation/s: nference, USA
Funder: Dr Corchado-Garcia reported receiving personal fees from and holding stock in nference Inc outside the submitted work. Dr Zemmour reported receiving personal fees from nference Inc outside the submitted work. Dr Hughes reported receiving personal fees from nference Inc during the conduct of the study; and personal fees from nference Inc outside the submitted work. Mr Lenehan reported receiving other fees from Janssen (nference collaborates with Janssen on data science projects unrelated to this manuscript, and this relationship did not impact the study design or interpretation of its results) outside the submitted work. Dr Pawlowski reported receiving personal fees from nference Inc outside the submitted work. Dr O’Horo reported receiving personal fees from Elsevier and Bates College; and grants from nference Inc, outside the submittedwork. Dr Badley reported being a consultant for AbbVie and Gilead; serving on scientific advisory boards for Freedom Tunnel, Pinetree Therapeutics, Primmune, Immunome, Flambeau Diagnostics, nference, and Zentalis; serving on data safety and monitoring boards for Corvus, Equillium, and Excision Biotherapeutics; and being founder and president of Splissen Therapeutics. Dr Virk reported being an inventor forMayo Clinic Travel App interaction with Smart Medical Kit and Medical Kit for Pilgrims. Dr Swift reported receiving grants from Pfizer during the conduct of the study. DrWagner reported receiving personal fees from and holding stock in nference Inc outside the submitted work. Dr Soundararajan reported other from Janssen (nference collaborates with Janssen and other biopharmaceutical companies on data science initiatives unrelated to this study, and these collaborations had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript outside the submitted work. TheMayo Clinic may stand to gain financially from the successful outcome of this research. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was in compliance with Mayo Clinic Conflict of Interest policies. No other disclosures were reported.
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