International
Around one in three people who got a placebo injection as part of a COVID-19 vaccine trial experienced side effects outside of the injection site according to an analysis of 12 trials. The study found that after the first dose, around one quarter of the side effects at the injection site were in those who received a placebo, while around three-quarters of the broader side effects, such as fatigue, muscle pain, headaches and fever, were in the groups who received a placebo. After the second dose, the vaccine group reported more side effects but around half of the broader side effects were still in the placebo group. The authors say telling people about these placebo side effects may help reduce worries about COVID-19 vaccination and decrease vaccination hesitancy.
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