Screening people for genetic risk could help prevent heart attacks and strokes

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Screening people for their genetic heart disease risk could help detect those likely to suffer a heart attack or stoke, allowing doctors to begin preventative treatment, say Australian and UK researchers. They found that, for those already with intermediate levels of heart disease risk, adding genetic risk screening to other screening tools could help prevent one cardiovascular disease event for every 340 people screened. If genetic screening was used for everyone aged 40–75 years, then it could help prevent one additional event for approximately every 5,750 individuals screened. The researchers say targeted use of genetic screening could translate into meaningful clinical benefit if applied at scale, and lead to the prevention of seven per cent more cardiovascular disease events than conventional risk factors alone.

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PLOS Medicine
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Organisation/s: Baker Heart and Diabetes Institute, University of Cambridge, UK
Funder: This work was supported by core funding from the UK Medical Research Council (MR/ L003120/1), the British Heart Foundation (RG/13/ 13/30194; RG/18/13/33946), and the National Institute for Health Research (NIHR) (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust). This work was supported by Health Data Research UK, which is funded by the the UK Medical Research Council, the Engineering and Physical Sciences Research Council, the Economic and Social Research Council, the Department of Health and Social Care (England), the Chief Scientist Office of the Scottish Government Health and Social Care Directorates, the Health and Social Care Research and Development Division (Welsh Government), the Public Health Agency (Northern Ireland), the British Heart Foundation, and Wellcome. Luanluan Sun, Lisa Pennells, Stephen Kaptoge, and Matthew Arnold are funded by a British Heart Foundation Programme Grant (RG/18/13/33946). Scott Ritchie, Mike Inouye, and Stephen Burgess are funded by the National Institute for Health Research (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust). David Stevens was funded by the National Institute for Health Research (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust). Thomas Bolton is funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Steven Bell was funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Angela Wood is supported by a BHF-Turing Cardiovascular Data Science Award and by the EC-Innovative Medicines Initiative (BigData@Heart). Professor John Danesh holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award. See paper for competing interests
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