Polycystic ovary syndrome linked to increased risk of pancreatic cancer

Embargoed until: Publicly released: 2022-10-07 02:00

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US researchers say there is a strong link between polycystic ovary syndrome (PCOS) and an increased risk of pancreatic cancer. The team asked female pancreatic tumour patients whether they had a history of PCOS, and compared their answers to a control group. They found a PCOS diagnosis was associated with a 1.9 times higher risk of pancreatic cancer, even after adjusting for other factors that could contribute. The team says this was independent of BMI, and largely not driven by type 2 diabetes. They add that their data suggest that some individuals may have a here-to-unknown metabolic issue that could underlie the development of both conditions.

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From:

Journal/
conference: JAMA Oncology

Research:Paper

Organisation/s: Memorial Sloan Kettering Cancer Center, USA

Funder: This study was supported by the National Cancer Institute (grants P30CA008748, R01CA154823, U01CA210171, and U01CA247283), the Geoffrey Beene Foundation, the Arnold and Arlene Goldstein Family Foundation, the Arnold and Arlene Goldstein Family Foundation, the Per and Astrid Heidenreich Foundation, and the MSKCC (the Gastroenterology, Hepatology, and Nutrition Research Fund; the David M. Rubenstein Center for Pancreatic Cancer Research; the Gastrointestinal Endoscopy Research Fund; and the Society of MSKCC).

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