Medicine could be helping bubs with low blood sugar sooner

Publicly released:
New Zealand
Photo by Juhan Sonin (CC BY 2.0)
Photo by Juhan Sonin (CC BY 2.0)

Auckland researchers have found that a medicine for babies with low blood sugar could be started much sooner, paving the way for a gentler, baby friendly approach to treatment. Currently, diazoxide is only used if a baby's low blood sugar persists for several weeks. However, the new study found a low dose of the medicine starting from day two helped babies to start normal feeding, to stop IV fluids sooner, and to reduce the number of low blood sugar episodes and blood tests needed.

Media release

From: Author summary from Chris McKinlay:

"Low blood glucose levels in newborn babies are common and are an important preventable cause of developmental impairment, but there is limited evidence to guide clinical practice. In this placebo-controlled clinical trial, we assessed a new approach to treating babies with severe or recurrent episodes of low blood glucose after birth that used a medicine called diazoxide. To date, diazoxide has been reserved for babies that have persisting low blood glucose for several weeks or a confirmed inherited disorder of glucose control. We found that using low dose diazoxide from the first day after birth largely eliminated further low blood glucose levels,  allowing babies to stop intravenous fluids and establish feeding more quickly. Diazoxide treatment also reduced the number of heel pricks that babies received for blood glucose monitoring. Early low dose diazoxide is a promising new treatment approach for newborn babies with low blood glucose levels."

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Research , Web page
Journal/
conference:
JAMA Network Open
Research:Paper
Organisation/s: University of Auckland, Te Whatu Ora - Health New Zealand, University of Canterbury
Funder: This work was funded by an Early Career Research Award from the University of Auckland (Dr McKinlay) and grant 20/651 from the Health Research Council of New Zealand (Dr Alsweiler, Prof Cutfield, Ms Rogers, Mr Gamble, Dr Chase, Prof Harding, and Dr McKinlay).
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