Australia; VIC
Australian researchers have profiled the connection between the immune system and metabolism in people with depression and have found that there is a persistent pattern of inflammation that can be seen before depressive symptoms arise. They found that this immunometabolic dysfunction, particularly elevated levels of inflammation, were linked with lower brain grey matter volume in depression. The authors say their findings suggest that disturbances in the connection between the immune and metabolic systems outside the brain may be linked to the risk of developing depression, and that early interventions that target this dysfunction could improve outcomes.
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