Long-acting medications could be an alternative to normal antibiotics for serious infections

Publicly released:
Australia; NSW
Image by Gerd Altmann from Pixabay
Image by Gerd Altmann from Pixabay

Long-acting medications called lipoglycopeptides, which are a type of semi-synthetic antibiotic, could be an alternative treatment to antibiotics for people with serious bacterial infections, according to Australian-led research. The long-acting drugs can be given in a single dose which can last multiple weeks. The study included around 42,000 people discharged from hospital after a serious bacterial infection, and around 800 (2%) of them were prescribed one of the long-acting drugs instead of normal antibiotics. The researchers found no statistically significant difference in outcomes between patients given the long-acting medications and those given antibiotics. The researchers say clinically, the drugs could be an effective alternative to standard antibiotic courses for serious bacterial infections.

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Research JAMA, Web page Please link to the article in online versions of your report (the URL will go live after the embargo ends).
Journal/
conference:
JAMA Network Open
Research:Paper
Organisation/s: The University of New South Wales, Kirby Institute, UNSW Sydney
Funder: This research was supported by internal funding from the UCLA Department of Medicine; grants K08 DA048163 and R01 DA057630 from the US National Institute on Drug Abuse (Dr Goodman-Meza); grant P30 MH58107 from the US National Institute on Mental Health through the UCLA Center for HIV Prevention and Treatment Services (Drs Goodman-Meza andWeiss); investigator grant 2008276 from the National Health and Medical Research Council (Dr Dore); the Australian Department of Health (Kirby Institute); and a grant from the National Institute of Biomedical Imaging and Bioengineering (Dr Feng).
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