IUD contraceptives linked to small increased risk of breast cancer

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Photo by Reproductive Health Supplies Co
Photo by Reproductive Health Supplies Co

Hormonal intrauterine devices (IUDs) for contraception are linked to a small increased risk of breast cancer compared to using no hormonal contraception, according to international researchers who say this increased risk is similar to the risk for taking an oral contraceptive pill. The researchers matched about 78,500 Danish women who had a levonorgestrel-releasing device such as the Mirena or Kyleena with a woman who did not use hormonal contraception and followed up over an average of 6.8 years to monitor breast cancer diagnoses. They say when adjusting for other risk factors, IUDs were associated with about 14 additional breast cancer cases per 10,000 women. The risk did not appear to change based on how long they used IUDs for, they add. The researchers say while the overall risk of breast cancer remains low, women should be informed of the possible risk when discussing their contraceptive options.

Media release

From: JAMA

About The Study: This Danish nationwide study found an association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and increased breast cancer risk in females ages 15 to 49, compared with nonuse. LNG-IUS use constitutes the preferred hormonal contraception among Danish premenopausal women older than 30 years. Although the absolute breast cancer risk is low in young women, this study found an excess risk of 14 per 10,000 females. The risk did not increase with duration of use.

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Research JAMA, Web page The URL will go live after the embargo ends
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conference:
JAMA
Research:Paper
Organisation/s: The Danish Cancer Institute, Denmark
Funder: Sundheds Donationer (health donations) funded this study (2021-0128 to Mørch).
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