Hold your horses: Caution urged around using ketamine for depression

Publicly released:
New Zealand
Photo by Priscilla Du Preez on Unsplash
Photo by Priscilla Du Preez on Unsplash

Despite "striking" results of short term improvements in depression, it's still unclear how well ketamine relieves mental illness long-term, researchers write in the latest editorial for the New Zealand Medical Journal. They say that the drug may become less effective for a patient over time, and it may mask underlying causes of mental distress, like socio-economic issues. They are also concerned about pharmaceutical companies possibly influencing both consumer and doctor demand, and the high risk of the drug being used recreationally, which both have echoes of the recent opiate epidemic in the US.

Media release

From: Pasifika Medical Association Group

Ketamine is an exciting new treatment for depression. Unfortunately, depression symptoms often  return after the course of ketamine ends. This creates challenges for clinicians wanting to use  ketamine in routine care. Other exciting treatments have offered promise previously, but the fullness of time is required to understand all the risks and benefits of new treatments.

Journal/
conference:
NZMJ
Organisation/s: University of Otago
Funder: Dr Beaglehole researches the impact of ketamine on mood and anxiety disorders using public funding. Prof Mulder has served on the data safety monitoring committee of a ketamine trial sponsored by Douglas Pharmaceuticals. The other author does not have any relevant conflicts of interest to declare.
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