Had COVID-19? Get vaccinated anyway

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If you’ve already had COVID-19, it’s still worth getting the vaccine, suggests international research. The team looked to see how well the virus was neutralised by antibodies from people who'd been vaccinated, people who'd been infected, and people who'd been both vaccinated and infected. And to really put these antibodies to the test - they developed a version of the virus spike protein with 20 specific mutations that made it more likely to escape the immune response. They found that people who were vaccinated or those who'd had COVID-19 were no longer able to neutralise this super spike protein, but people who'd been both infected and vaccinated had antibodies that could neutralise it. Since it’s not ideal to become infected with COVID-19, researchers suggest looking at whether booster jabs can create the same broad response is important. They also suggest using this highly mutated spike protein to create vaccines may be one way to help broaden the immune response.

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conference:
Nature
Research:Paper
Organisation/s: The Rockefeller University, USA
Funder: This work was supported by NIH grants R37AI64003 and R01AI501111 (P.D.B).; R01AI78788 (TH); P01-AI138398-S1 (M.C.N.) and 2U19AI111825 (M.C.N.). C.G. was supported by the Robert S. Wennett Post-Doctoral Fellowship, in part by the National Center for Advancing Translational Sciences (National Institutes of Health Clinical and Translational Science Award programme, grant UL1 TR001866), and by the Shapiro–Silverberg Fund for the Advancement of Translational Research. P.D.B. and M.C.N. are Howard Hughes Medical Institute Investigators.
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