Gut microbes linked to endometriosis

Embargoed until: Publicly released: 2024-10-12 02:00

International

Image by LJNovaScotia from Pixabay

Researchers analysed stool samples from 18 women with, and 31 women without, endometriosis, and found differences in the presence or absence of certain types of molecules, or 'metabolites', produced by microbes. They then experimented on mice by giving them endometriosis and feeding them one type of metabolite, finding this could stop and even undo disease progression. The metabolites they identified have some overlap with those in Inflammatory Bowel Disease, and the authors suggest both diseases could be linked to gut microbe composition. They say larger studies are needed, but their findings show potential for non-invasive diagnosis using stool samples.

Attachments

Note: Not all attachments are visible to the general public. Research URLs will go live after the embargo ends.

Research Cell Press, Web page URL will go live after the embargo lifts

Journal/
conference: Med

Research:Paper

Organisation/s: Baylor College of Medicine - Texas, USA

Funder: This work was funded, in part, by National Institutes of Health/National Institute of Child Health and Human Development (grants R01HD102680 and R01HD104813) and a Research Scholar Grant from the American Cancer So- ciety to R.K. The metabolomics core was supported by the CPRIT Core Facility Support Award RP210227 ‘‘Proteomic and Metabolomic Core Facility,’’ NCI Cancer Center Support Grant P30CA125123, NIH/NCI R01CA220297, and NIH/NCI R01CA216426 intramural funds from the Dan L. Duncan Cancer Cen- ter (DLDCC). The Baylor College of Medicine Intellectual and Developmental Disabilities Research Center is supported by funding from NICHD (P50HD103555). The Mouse Phenotyping Core at Baylor College of Medicine is supported with funding from theQ9 NIH (U54 HG006348). The graphical ab- stract was created with BioRender.com (license number: OA275XNJR3). We thank Dr. Pooja Popli and Dr. Sangappa B. Chadchan, Department of Pathol- ogy & Immunology, Baylor College of Medicine, Houston, TX for technical assistance and for assisting with manuscript editing.

Media Contact/s

Contact details are only visible to registered journalists.