COVID mRNA jabs not associated with negative health effects

Embargoed until: Publicly released: 2021-09-04 01:00

International

Getting an mRNA COVID vaccine, such as the Comirnaty Pfizer-Biontech or Moderna vaccine, will not put you at a higher risk of serious health issues such as appendicitis, stroke and heart issues, according to international researchers who monitored patients for adverse events up to 42 days after their first or second dose. The team used vaccine surveillance data from 6.2 million people who received 11.8 million doses of a mRNA vaccine, and found adverse events for 23 serious health outcomes weren’t higher for people 1-21 days after vaccination compared with those 22-42 days after vaccination. The team found mRNA COVID-19 vaccines were safe for the population overall, but an excess risk of heart issues was identified for vaccinated people aged 12 to 39 years. Anaphylaxis after mRNA vaccination was also rare. While these findings are positive, the team says they will continue to follow up to ensure vaccine safety.

Media release

From: JAMA

Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 3, 2021

What The Study Did: In this interim analysis of surveillance data from 6.2 million people who received 11.8 million doses of an mRNA vaccine, event rates for 23 serious health outcomes weren’t significantly higher for individuals one to 21 days after vaccination compared with similar individuals at 22 to 42 days after vaccination.

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Research JAMA, Web page The URL will go live after the embargo ends.

Journal/
conference: JAMA

Research:Paper

Organisation/s: Kaiser Permanente Northern California, USA

Funder: This study was supported by grant funding from the CDC, contract 200-2012-53581/0001. Dr Klein reported receiving grants from the Centers for Disease Control and Prevention (CDC) during the conduct of the study, and grants from Pfizer, Merck, GSK, Sanofi Pasteur, and Protein Science (now SP) outside the submitted work. Ms Hanson reported receiving grants from CDC during the conduct of the study. Dr Donahue reported receiving grants from CDC during the conduct of the study and from Janssen Vaccines & Prevention for a study unrelated to COVID-19 vaccines. Dr Kharbanda reported receiving other from CDC (contract 200-2012-53526) during the conduct of the study

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