Changes in single genes may be involved in half of ADHD cases, small study suggests

Embargoed until: Publicly released: 2023-11-21 03:00

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A small study which sequenced the entire DNA of 77 kids with ADHD and their families in the US has found that variations in single genes may account for a significant portion of the genetics underlying ADHD. ADHD is usually thought of as a disorder that involves multiple genes, but these researchers found that 52% of the ADHD cases they looked at were explained by one-off or inherited variations in single genes, and that this was similar to rates seen in Autism Spectrum Disorder.

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Journal/
conference: JAMA Pediatrics

Research:Paper

Organisation/s: Boston Children’s Hospital, USA

Funder: This project was supported by Boston Children’s Hospital (Dr Doan). Whole exome sequencing was funded by the Children’s Rare Disease Cohort initiative at Boston Children’s Hospital

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