Booster protection against symptomatic Omicron wanes after 10 weeks

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When it comes to preventing all COVID-19 symptoms, the effectiveness of boosters wanes after 10 weeks, according to a UK study. The study looked at the effectiveness of two and three doses of vaccine against symptomatic disease from the Omicron variant in the UK. It found that after 20 weeks, two doses of the AstraZeneca vaccine had no impact on preventing COVID-19 symptoms from Omicron, while two doses of the Pfizer vaccine had an efficacy of just 8.8 per cent. Boosters did improve the efficacy of vaccines - but this too started to wane after 10 weeks. The efficacy of a Pfizer booster dropped to around 40-45 per cent after 10 weeks, while Moderna booster efficacy was around 60-65 per cent after 10 weeks.  The study did not look at their efficacy against severe disease or death.

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Research Massachusetts Medical Society, Web page Please link to the article in online versions of your report
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New England Journal of Medicine
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Organisation/s: U.K. Health Security Agency
Funder: Supported by the U.K. Health Security Agency (UKHSA). Dr. Simons is supported by a doctoral training grant from the Biotechnology and Biological Sciences Research Council (grant number BB/M009513/1).
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