After breast cancer it may be safe to pause hormone therapy to try to get pregnant

Embargoed until: Publicly released: 2023-05-04 07:00

Australia; International; VIC

For women who have had hormone receptor–positive breast cancer, temporarily stopping their ongoing hormone therapy to try to get pregnant does not appear to increase the risk of breast cancer reoccurring in the short term, according to Australian and international researchers. The study found that the 3-year incidence of breast cancer was 8.9% in the group that paused treatment and 9.2% in a control group that did not pause treatment.

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Journal/
conference: New England Journal of Medicine

Research:Paper

Organisation/s: The University of Melbourne, Dana–Farber Cancer Institute, USA

Funder: Supported by the ETOP IBCSG Partners Foundation (globally) and by the Alliance for Clinical Trials in Oncology (in North America), in collaboration with the Breast International Group (BIG), the BIG cooperative groups, and the National Clinical Trials Network of the National Cancer Institute. Globally, the trial receives grant support for central or local trial conduct from the following: the International Breast Cancer Study Group (IBCSG); Frontier Science and Technology Research Foundation, Southern Europe (Frontier Southern Europe), Pink Ribbon Switzerland, Swiss Cancer League (KLS-3361-02), San Salvatore Foundation, Rising Tide Foundation for Clinical Cancer Research (CCR-15-120), Swiss Group for Clinical Cancer Research, Clinical Cancer Research Foundation of Eastern Switzerland, Roche Diagnostics International, Swiss Cancer Foundation, Piajoh Fondazione di Famiglia, Gruppo Giovani Pazienti “Anna dai Capelli Corti,” Verein Bärgüf, and Schweizer Frauenlauf Bern — all in Switzerland; BIG Against Breast Cancer and the Baillet Latour Fund, Belgium; Gateway for Cancer Research (G-15-1900) and Breast Cancer Research Foundation — both in the United States; C & A, Germany; Dutch Cancer Society, the Netherlands; Norwegian Breast Cancer Society and Pink Ribbon — both in Norway; ELGC K.K. and Pink Ring — both in Japan; Korea Breast Cancer Foundation and Mr. Yong Seop Lee — both in South Korea; and other private donors. In North America, the Alliance for Clinical Trials in Oncology receives support from the National Cancer Institute of the National Institutes of Health (NIH) (Alliance for Clinical Trials in Oncology National Cancer Institute Community Oncology Research Program [NCORP] grant UG1CA189823) and the biorepository resource grant U24CA196171; the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network (ECOG-ACRIN) receives support under ECOG-ACRIN NCORP grants UG1CA189828 and UG1CA233196; Southwest Oncology Group Cancer Research Network receives support under NIH grants UG1CA189974 and U10CA180888; and NRG Oncology receives support under NIH grant U10CA180868 and NCORP grant UG1CA189867. Canadian Cancer Trials Group (CCTG) participation in the trial is supported through its grant from the National Cancer Institute of the NIH (CA180863). Additional programmatic funding support for the CCTG is provided by the Canadian Cancer Society (707213) and the Canada Foundation for Innovation. In addition, the trial receives support from RETHINK Breast Cancer, Canada, and the Gilson Family Foundation, United States.

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