A 63 year old man is in remission from HIV after a stem cell transplant to treat cancer

Embargoed until: Publicly released: 2024-02-15 09:00

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A 63 year old man has been in remission from HIV for 5 years after he received a stem cell transplant to treat his leukaemia. The patient needed a stem cell transplant to treat his cancer, so the team looked for a donor with a mutation in a gene known as CCR5, which is known to be related to resistance to HIV infection. The authors say this case has shown that older patients who are undergoing stem cell transplants for the treatment of cancer may also be cured of HIV-1 infection.

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Journal/
conference: New England Journal of Medicine

Research:Paper

Organisation/s: City of Hope National Medical Center, USA

Funder: Supported by the Analytical Pharmacology Shared Resource at City of Hope with a grant (USPHS P30CA033572) from the National Cancer Institute, a grant (CIRM INFR4-13857) from the City of Hope Alpha Stem Cell Clinic funded by the California Institute for Regenerative Medicine, a grant (to Dr. Zaia) from the Judith Owens Trust, a grant (USPHS P30 AI036214) from the Translational Virology Core at the San Diego Center for AIDS Research, a grant (USPHS R01 MH128153, to Dr. Chaillon) from the National Institutes of Health (NIH), and grants to Accelevir Diagnostics (USPHS U24AI143502 and USPHS R44AI124996) from the NIH and a grant (NSF 1738428) from the National Science Foundation.

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