Women with BRCA genes who get breast cancer within 10 years of giving birth more likely to die

Embargoed until: Publicly released: 2024-04-20 01:00

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US and UK scientists looked at data for 903 British women with cancer-causing BRCA genes, and found those who were diagnosed with breast cancer within 10 years of giving birth were more likely to die from the disease than women who were diagnosed later and women who had not given birth. The highest risk was seen among women with the BRCA1 gene who were diagnosed with oestrogen receptor positive breast cancer within five years of giving birth and women with BRCA1 diagnosed with oestorogen negative breast cancer between five and 10 years after giving birth. The same pattern was not seen among women with the BRCA2 gene, however. The researchers say their results should be used to inform genetic counseling, prevention, and treatment strategies for women with BRCA genes.

Media release

From: JAMA

Postpartum Breast Cancer and Survival in Women With Germline BRCA Pathogenic Variants

About The Study: This study including 903 women with BRCA germline pathogenic variants found that a breast cancer diagnosis less than 10 years postpartum was associated with higher risk of mortality compared with nulliparous women and women diagnosed at least 10 years postpartum. These results should inform genetic counseling, prevention, and treatment strategies for BRCA pathogenic variant carriers.

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Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: Oregon Health & Science University, USA

Funder: This project was supported by funding from the Oregon Health & Science University’s Knight Cancer Institute (Dr Zhang), the National Institute of Health (NIH) Office of Research onWomen’s Health and the National Institute of Child Health and Human Development Building Interdisciplinary Research Careers inWomen’s Health (grant No. K12HD043488; Dr Zhang), a grant from the ACED (grant No. ACED7250220), the NIH National Cancer Institute (grant No. R01CA169175; Dr Schedin), the Prevent Cancer Foundation Fellowship (Dr Bernhardt), and the resources to Dr Schedin from the Willard L. and Ruth P. Eccles and Leonard Schnitzer Family Foundations. We also thank the Knight Cancer Institute’s Cancer Center Support (grant No. P30CA69533).

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