Advanced nanotechnology to improve success of dental implants

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Peer-reviewed: This work was reviewed and scrutinised by relevant independent experts.

Experimental study: At least one thing in the experiment was changed to see if it had an impact on the subjects (often people or animals) – eg: changing the amount of time mice spend on an exercise wheel to find out what impact it has on weight loss.

Cells: This is a study based on research in micro-organisms, cells, tissue, organs or non-human embryos.

A technological advancement that may prove crucial in the long-term success of dental implants has been developed by University of Queensland researchers.

Journal/conference: Materials Science and Engineering: C

Link to research (DOI): 10.1016/j.msec.2020.110860

Organisation/s: The University of Queensland

Funder: Financial support from Australian Dental Research Foundation (ADRF) grant numbers 241-2017 and 249-2017.

Media release

From: The University of Queensland

A technological advancement that may prove crucial in the long-term success of dental implants has been developed by University of Queensland researchers.

Dr Karan Gulati, NHMRC Early Career Fellow from the UQ School of Dentistry, said modifying dental implants with ‘nanopores’ will help protect against one of the leading causes of implant failure.

“Poor integration between the implant and the surrounding tissue is one of the leading causes of dental implant failure,” Dr Gulati said.

“If the sealing between the implant and the surrounding gum tissue fails it can result in bacteria entering the implant and causing infection.

“Our simple solution is the fabrication of nanopores ⁠— which are tiny nano-scale holes of just 40 to 80 nanometres in diameter ⁠— to cover the entire surface of the implant.

“We’ve found that soft-tissue cells attach well onto the nanopores, resulting in better soft-tissue seal formation.

“We can also control the cell functions to achieve a more enhanced soft-tissue integration.”

Dr Gulati said that dental implant failure represents an economic and health burden in Australia.

“The failure rate of dental implants is generally five to 10 per cent, and for smokers it can be up to 20 per cent,” he said.

“Failure is more common in older patients, smokers, people with poor oral hygiene, and those with ongoing health conditions, such as diabetes and osteoporosis.

“From a financial point of view, implant failure can result in a patient paying thousands of dollars more on top of the cost of the original dental implant.

“This advancement of nanotechnology is a crucial step in improved oral health for the community.”

Dr Gulati is hopeful that human trials will begin next year.

“We have optimised the protocols and the therapies, now we are ready to turn the research into reality,” he said.

“We are currently seeking funding to enable us to purchase additional equipment and recruit staff so that clinical translation can commence.”

The proof of concept study is published in Materials Science and Engineering: C.

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