Spatial mapping lung tumours reveals unusual T‑cells linked to earlier relapse

Embargoed until: Publicly released: 2026-02-10 09:55

Australia; VIC

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WEHI researchers have used advanced spatial multi‑omics to map the immune ecosystem of non‑small cell lung cancer, uncovering an unusual T cell population linked to relapse and poorer outcomes. The new study revealed a CD14⁺CD4⁺ T cell type that has never been seen before in lung cancer. The research outlines a new immunosuppressive circuit that may help lung tumours progress. The WEHI team is now exploring ways to potentially block this cell type in lung cancer, to prevent relapse.