No link between COVID-19 vaccines and early pregnancy loss

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Photo by John Looy on Unsplash
Photo by John Looy on Unsplash

An international study has found no link between COVID-19 vaccinations and miscarriages early on in pregnancy. Using Norwegian registries on first trimester pregnancies, COVID-19 vaccinations and relevant health conditions, the researchers analysed data on a group of women who had been vaccinated in the weeks leading up to either a miscarriage or an ongoing pregnancy. The researchers say they found no evidence of a link between the vaccination and miscarriages, which they say adds to a growing list of research supporting the safety of vaccinations for pregnant women. Norway currently uses the Pfizer, Moderna, and Janssen vaccines.

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Expert commentary by Dr Alex Polyakov, Obstetrician and Senior Clinical Lecturer at the University of Melbourne

There is a lot of misinformation regarding possible effects of COVID-19 vaccinations on pregnancy and fertility. These unfounded concerns are amplified by social media which creates vaccine hesitancy among people who are trying to conceive as well as pregnant women. Millions of women in these circumstances have been vaccinated up to date and there is no suggestion that COVID-19 vaccination has any impact on either short- or long-term fertility. Likewise, despite constant and extremely close monitoring, there is no evidence that COVID-19 vaccines cause any problems in early or late pregnancy. Nor do they have any negative impact on the risk of miscarriage. This Norwegian study concentrated on the risk of miscarriage and its possible association with COVID-19 vaccinations. The results are reassuring in that it found no increased risk of miscarriage following either one or two doses of COVID-19 vaccination. This reinforces previous research that supports the safety of COVID-19 vaccination at any stage of pregnancy, including very early pregnancy. It is becoming clear, as more research and surveillance is conducted, that the risk of COVID-19 vaccination is minimal for the vast majority of women. At the same time, COVID-19 infection poses an unacceptably high risk of severe disease and even death, and this risk appears to be greater for pregnant women compared to the general population. The message is clear: there are very few reasons not to get vaccinated and trying to conceive or being pregnant are not one of them.

Last updated:  22 Oct 2021 9:14am
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Research Massachusetts Medical Society, Web page
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conference:
New England Journal of Medicine
Research:Paper
Organisation/s: Norwegian Institute of Public Health
Funder: Supported in part by the Research Council of Norway (project number, 324312) and through its Centers of Excellence funding scheme (project number, 262700) and by NordForsk (project number, 105545). Dr. Magnus has received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation program (grant agreement number, 947684). The funders had no role in the completion of the research project, the writing of the manuscript for publication, or the decision to submit the manuscript for publication.
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