mRNA COVID-19 vaccines are safe during early pregnancy

Embargoed until: Publicly released: 2025-10-16 02:00

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It is very unlikely that mRNA COVID-19 vaccines cause birth defects, say international researchers who looked at data from over half a million newborn babies. The team found no association between taking the vaccine in the first trimester of pregnancy and an increased risk of 75 different major birth defects. The authors say their findings align with previous research and further reinforce the safety of mRNA COVID-19 vaccines during pregnancy.

Media release

From: JAMA

First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies

About The Study: In this cohort study of pregnancies exposed to messenger RNA (mRNA) COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any major congenital malformations, overall, by organ group, or by individual major congenital malformation, supporting the safety of mRNA COVID-19 vaccines in early pregnancy.

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Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: French National Agency for Medicines and Health Products Safety (ANSM), France

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