High quality evidence suggest intermittent fasting can actually help you lose weight

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Peer-reviewed: This work was reviewed and scrutinised by relevant independent experts.

Meta-analysis: This type of study involves using statistics to combine the data from multiple previous studies to give an overall result. The reliability of a meta-analysis depends on both the quality and similarity of the individual studies being grouped together.

People: This is a study based on research using people.

A mega-analysis of previous research, which brings together and re-analyses the results of previous meta-analyses, has found that intermittent fasting, especially modified alternate-day fasting, is a useful way for overweight or obese adults to lose weight. The research pulled together 11 previous meta-analyses, which themselves looked at a total of 130 different trials, and found there was high-quality evidence that modified alternate-day fasting, for one to two months, was linked to a reduction in body mass index in adults compared with a regular diet. There was also moderate evidence of other benefits including the use of zero-calorie alternate-day fasting for the reduction of fat mass and the 5:2 diet for the reduction of fasting insulin in adults with overweight or obesity compared with a regular diet.

Journal/conference: JAMA Network Open

Link to research (DOI): 10.1001/jamanetworkopen.2021.39558

Organisation/s: Chulalongkorn University, Thailand, University of Utah, USA

Funder: Conflict of Interest Disclosures: Dr Pham reported receiving personal fees for the Southwest Obesity Symposium outside the submitted work. Dr Varady reported receiving author fees from Hachette Book Group for the book, The Every Other Day Diet. No other conflicts were reported.

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