Gender-affirming treatments may be altering the hearts of trans people

Embargoed until: Publicly released: 2025-07-31 01:00

International

Photo by Aakash Dhage on Unsplash

A study of 120 transgender individuals has found gender-affirming hormone therapies may alter heart rhythms to match their target gender, according to international researchers who say these heart changes should be noted, especially when prescribing other medications. The team looked at electrocardiograms to measure the properties of the hearts of 64 transgender men treated with testosterone, and 56 transgender women treated with antiandrogens. They found the hormone treatments were linked with lengthening of the time interval taken for the heart to 'recharge' between beats in trans women, but shortening in trans men – making them more similar to the interval seen in cisgender adults.

Attachments

Note: Not all attachments are visible to the general public. Research URLs will go live after the embargo ends.

Research JAMA, Web page The URL will go live after the embargo lifts.

Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: Sorbonne Université, France

Funder: Clinical Investigation Center 1901 was funded by the Institut National de la Santé et de la Recherche Médicale and Direction Générale de l’Offre de Soins. Role of the Funder/Sponsor: Clinical Investigation Center 1901 was involved in the management of the study but not in the analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Media Contact/s

Contact details are only visible to registered journalists.