Tareq Ismail on Unsplash
Tareq Ismail on Unsplash

Fried food may increase risk of cardiovascular disease

Embargoed until: Publicly released:
Peer-reviewed: This work was reviewed and scrutinised by relevant independent experts.

Meta-analysis: This type of study involves using statistics to combine the data from multiple previous studies to give an overall result. The reliability of a meta-analysis depends on both the quality and similarity of the individual studies being grouped together.

People: This is a study based on research using people.

Studies reporting a link between eating fried foods and cardiovascular disease often contradict each other, but a meta-analysis has provided evidence for such an association. Chinese researchers examined the results from six studies, involving three quarters of a million participants, and found that risks of major cardiovascular events, coronary heart disease, and heart failure increased as more fried food was eaten each week. The authors caution though that variation in the published studies and their reliance on peoples’ memory of what they ate mean that further research is required. The cause of the link between fried food and cardiovascular disease remains uncertain.

Journal/conference: Heart

Link to research (DOI): 10.1136/heartjnl-2020-317883

Organisation/s: Shenzhen University Health Science Center, China

Funder: National Natural Science Foundation of China; the Natural Science Foundation, the Medical Research Foundation of Guangdong Province; the Science and Technology Development Foundation of Shenzhen

Media release

From: The BMJ

Fried food intake linked to heightened serious heart disease and stroke risk

Risk rises with each additional weekly 114 g serving, pooled data analysis shows

Fried-food intake is linked to a heightened risk of major heart disease and stroke, finds a pooled analysis of the available research data, published online in the journal Heart.

And the risk rises with each additional 114 g weekly serving, the analysis indicates.

It’s clear that the Western diet doesn’t promote good cardiovascular health, but it’s not clear exactly what contribution fried food might make to the risks of serious heart disease and stroke, say the researchers.

To shed some light on this, they trawled research databases, looking for relevant studies published up to April 2020, and found 19.

They pooled the data from 17, involving 562,445 participants and 36,727 major cardiovascular ‘events’, such as a heart attack or stroke, to assess cardiovascular disease risk. 

And they pooled the data from six, involving 754,873 participants and 85,906 deaths over an average monitoring period of 9.5 years, to assess the potential link between fried food consumption and deaths from cardiovascular disease and from any cause.

Their analysis showed that compared with the lowest category of weekly fried food consumption, the highest was associated with a 28% heightened risk of major cardiovascular events; a 22% heightened risk of coronary heart disease; and a 37% heightened risk of heart failure. 

These associations held true when stratified by various study and participant characteristics. What’s more, a linear association emerged between fried food consumption and major cardiovascular events, coronary heart disease, and heart failure.

These risks substantially increased by 3%, 2%, and 12%, respectively, in tandem with each additional 114 g weekly serving.

Several studies included only one type of fried food, such as fried fish, potatoes, or snacks, rather than total fried food intake, which may have underestimated the associations found, suggest the researchers. 

No associations were found for deaths from cardiovascular disease or from any cause, but this might be because of the relatively small numbers involved, say the researchers.

The design of the included studies varied considerably, added to which, they all relied on memory--factors that should be taken into consideration when interpreting the results, caution the researchers.

And how exactly fried foods might influence the development of cardiovascular disease isn’t entirely clear, they point out, but suggesting several possible explanations.

Fried foods boost energy intake because of their fat content and they generate harmful trans fatty acids from the hydrogenated vegetable oils often used to cook them.

Frying also boosts the production of chemical by-products involved in the body’s inflammatory response, while foods, such as fried chicken and French fries, are usually high in added salt, and often accompanied by sugar-sweetened drinks, particularly when served in fast food restaurants, they say.

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