For healthy ageing, it's all about how you feel, and cheese helps, apparently

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Whether you're rich or poor, your mental wellbeing may be the most important factor in determining how healthy you are as you age, according to Chinese scientists who looked at eight different genetic datasets, including a total of 2.3 million Europeans. Using a technique called ‘Mendelian randomisation’ - which uses DNA to see whether one thing causes another, rather than them just being linked - they found that people with better mental wellbeing tended to be healthier as they aged, with healthy ageing characterised by improved resilience, higher self-rated health, and longevity. Although this held true regardless of people's financial background, they also found that higher earnings, a higher level of education, and people's jobs all had an influence on their wellbeing. To improve your wellbeing, they found being active and not smoking helped, as well as, slightly randomly, eating more cheese and fruit. A bigger focus on maintaining people's wellbeing could help them stay healthy as they age, the scientists conclude.

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From: Springer Nature

Mental well-being promotes healthy ageing

Mental well-being is associated with healthy ageing, independent of socioeconomic status, according to a study published in Nature Human Behaviour. The findings suggest the importance of mental health in promoting longevity and stress resilience in ageing.

The connection between mental well-being and physical health outcomes has been the subject of extensive research and debate. Previous observational studies have suggested a link between positive mental health and enhanced ageing processes, including a reduced propensity for disease and increased lifespan. However, the causal nature of this relationship has remained unclear, largely owing to potential confounding factors, such as personal socioeconomic status, and the challenge of reverse causality.

Tian-Ge Wang and colleagues analysed publicly available genetic data on people of European-descent to examine the effect of mental well-being on different outcomes of ageing. In an analysis of datasets with a maximum of 2.3 million people, they found that individuals with better mental well-being tend to experience healthier ageing (characterized by improved resilience, higher self-rated health, and longevity).

Through their analysis of 8 datasets with 800,000 to 2.3 million people, Wang and colleagues note that income, education, and occupation were all associated with better mental well-being, and that increased income was the most strongly related. Additionally, after screening 106 candidate mediators, they report that decreases in measures of a sedentary lifestyle (for example, TV watching time) and smoking, as well as, for example, increases in the intake of cheese and fruit, may lead to improvements in well-being and healthier ageing.

The findings highlight the importance of integrating mental health support into public health policies and ageing research. The authors suggest that interventions aimed at improving mental well-being could be a viable strategy to enhance healthy ageing across populations. However, the study’s reliance on data from individuals of European descent means there is a need for further validation of these findings across more diverse ethnic groups.

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conference:
Nature Human Behaviour
Research:Paper
Organisation/s: Shanghai Jiao Tong University School of Medicine, China
Funder: This work was supported by the grants from the National Natural Science Foundation of China (82370820, 82088102, 91857205, 823B2014 and 81930021), the ‘Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant Support’ from Shanghai Jiao Tong University School of Medicine (20171901 Round 2), and the Innovative Research Team of High-level Local Universities in Shanghai.
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