Photo by Alexander Grey on Unsplash
Photo by Alexander Grey on Unsplash

Exposure to a common type of medication could make you age faster

Embargoed until: Publicly released:
Peer-reviewed: This work was reviewed and scrutinised by relevant independent experts.

Observational study: A study in which the subject is observed to see if there is a relationship between two or more things (eg: the consumption of diet drinks and obesity). Observational studies cannot prove that one thing causes another, only that they are linked.

People: This is a study based on research using people.

High exposure to a type of drug often used to treat a range of medical conditions is linked to a faster decline in physical performance in older age, according to Australian and international research. Anticholinergic drugs are used to treat conditions including Parkinson’s disease, chronic obstructive pulmonary disease (COPD), and bladder problems, and some antidepressants and antihistamines also have anticholinergic properties. The researchers monitored the change in walking speed and grip strength of over 4000 older adults over time and compared this with their exposure to anticholinergic medications over a decade. They say while grip strength appeared unaffected, a higher exposure to anticholinergics was linked to a greater decline in walking speed.

Journal/conference: JAMA Network Open

Research: Paper

Organisation/s: South Australian Health and Medical Research Institute (SAHMRI), University of Washington, USA

Funder: This research was funded by the National Institute on Aging (grant No. U19AG066567) and the Plein Center for Aging (University ofWashington School of Pharmacy). Data collection for this work was additionally supported, in part, by prior funding from the National Institute on Aging (grant No. U01AG006781).

Media release

From: JAMA

About The Study: In this cohort study, higher anticholinergic exposure was associated with accelerated decline in physical performance, consistent with clinically meaningful decline. These findings suggest that minimizing anticholinergic medications is important for healthy aging.

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