Does lithium deficiency play a role in Alzheimer's disease?

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Photo by Justin Wolff on Unsplash
Photo by Justin Wolff on Unsplash

Lithium deficiency may play a role in the degeneration of the brain that leads to the onset of Alzheimer's disease and replacing lithium could help prevent and treat the condition, according to US research in mice. The researchers found that reducing the levels of lithium in the brains of mice leads to signs of Alzheimer's disease and accelerated cognitive decline. They also found that replacing this missing lithium with a lithium salt prevents the brain changes and memory loss in mouse models of Alzheimer's as well as in regular ageing mice. The authors say replacing lithium with these lithium salts is a potential approach to the prevention and treatment of Alzheimer's disease.

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Nature
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Organisation/s: Harvard Medical School, USA
Funder: This work was supported by NIH grants RO1AG046174 and RO1AG069042 to B.A.Y.; K01AG051791 and DP2AG072437 to E.A.L.; P30AG10161, P30AG72975, R01AG15819, R01AG17917, U01AG46152 and U01AG61356 to D.A.B.; and grants from the Ludwig Family Foundation, the Glenn Foundation for Medical Research and the Aging Mind Foundation to B.A.Y.
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