An Ozempic-like drug used for diabetes could also help early stage Parkinsons

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Photo by Milada Vigerova on Unsplash
Photo by Milada Vigerova on Unsplash

A drug used for diabetes, which works in a similar way to Ozempic, has shown some promise in a clinical trial for early-stage Parkinson's disease. The drug, lixisenatide, is a glucagon-like peptide-1 receptor agonist and compared to placebo it has been found to help slow the progression of motor disability after 12 months in a small phase 2 trial. The researchers also found significant gastrointestinal side effects including nausea in 46% of people receiving lixisenatide, and vomiting in 13%. They say longer and larger trials are needed to determine the effects and safety of lixisenatide in persons with Parkinson’s disease.

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Research Massachusetts Medical Society, Web page Please link to the article in online versions of your report (the URL will go live after the embargo ends).
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conference:
New England Journal of Medicine
Research:Paper
Organisation/s: French Clinical Research Network (F-CRIN) for Parkinson’s Disease and Movement Disorders, University of Toulouse 3
Funder: Supported by grants from the French Ministry of Health (PHRC-N program, PHRC-16-0402) and Cure Parkinson’s (in partnership with the Van Andel Institute).
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