Long-term disabilities may be linked to TB

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It’s estimated that a quarter of the world’s population is infected with tuberculosis (TB). Now these people are being given a fighting chance to avoid long-term disability caused by the disease thanks to research undertaken at The Australian National University (ANU) in partnership with the World Health Organization. The team reviewed over 130 publications, assessing a total of 175 data sets, which were generated using information on over 200,000 patients with TB. The researchers found that among a range of disabilities associated with TB, mental health disorders, respiratory impairments and musculoskeletal impairments were the most common.

Media release

From: The Australian National University

It’s estimated that a quarter of the world’s population is infected with tuberculosis (TB). 

Now these people are being given a fighting chance to avoid long-term disability caused by the disease thanks to world-first research undertaken at The Australian National University (ANU) in partnership with the World Health Organization.

Despite being both curable and preventable, every day, nearly 28,000 people will be diagnosed with TB and 4,000 people will lose their lives to the disease. It’s one of the world’s deadliest diseases and for those who don’t lose their lives, TB can cause significant long-term disability.

Until now, little has been known about the prevalence of TB related disability and the researchers are the first to examine disabilities caused by the disease at a global scale.

“This is the first systematic review that has attempted to synthesise the global literature on all TB related disability,” Dr Samantha Colquhoun from the National Centre for Epidemiology and Population Health at ANU said.

The team reviewed over 130 publications, assessing a total of 175 data sets, which were generated using information on over 200,000 patients with TB. The researchers found that among a range of disabilities associated with TB, mental health disorders, respiratory impairments and musculoskeletal impairments were the most common.

The research has global significance for the treatment of TB related disabilities. Researchers have mapped the spectrum and prevalence of TB related disabilities, and believe that this information is critical to ensure health services and policy in countries can provide appropriate care to patients where TB is common.

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Research The Australian National University, Web page https://link.springer.com/epdf/10.1186/s12916-021-02063-9?sharing_token=s3uRbf_-Q17t9AlVDXB71G_BpE1tBhCbnbw3BuzI2ROPayEsMF3vqy5HeR0nm_Gbm6MFLjXhL17FCO3qiNbBT3H1_77AolBbEMMupXSMUToZA0-C-MXYYux77KRnhhIwz5CbTjrvtI-T2UXmbrSvzd69ZtHGafl49KljbKRjc2o%3D
Journal/
conference:
BMC Medicine
Research:Paper
Organisation/s: The Australian National University, Curtin University, The University of New South Wales, Telethon Kids Institute, The University of Sydney, Bond University
Funder: This review was funded by the End TB Unit, World Health Organization Regional Office for the Western Pacific, under an Agreement for Performance of Work contract, with Australian National University. In-kind support was provided by the Australian National University, Curtin University, the Telethon Kids Institute, The University of Sydney, and Bond University. KV is supported by a Sidney Sax Early Career Fellowship from the Australian National Health and Medical Research Council (NHMRC), Canberra ACT, Australia (GNT1121611). SC is supported by NHMRC ISER Centre for Research Excellence grant (APP1107393). KAA is funded by NHMRC Investigator Grant (APP1196549). The funders provided no input into the undertaking or reporting of the research.
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