Australia; QLD
What we know about the effectiveness of COVID-19 antiviral drugs largely comes from their use on unvaccinated people infected with the Delta variant - a group that now forms only a small part of our community, say Australian experts. They say the trials took place before the emergence of the Omicron variant, and most Australians are now vaccinated. The drugs are now being used in patients who have received two doses of vaccine but have not received a booster dose, but it is unknown whether the drugs will remain clinically effective or cost-effective in these people. They say the rapid TGA approval and PBS listing of oral drugs also risks medication issues when community prescribers have limited access to specialist advice and support.
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