What's the best course of action for people at risk of ovarian cancer

Embargoed until: Publicly released: 2026-07-08 01:00

Australia; International; VIC

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Interval salpingectomy with delayed oophorectomy (ISDO) - the removal of just the fallopian tubes - could result in a person having better sexual function than having risk-reducing salpingo-oophorectomy (RRSO) - The removal of both the fallopian tubes and ovaries - for women who are at high risk of developing ovarian cancer, say US and Aussie researchers. The team looked into the results from a trial including 426 premenopausal patients who were planning risk-reducing surgery, and say a significantly lower proportion of the people who were having the ISDO surgery had reductions in their ability to experience sexual pleasure and satisfaction when desired, when compared to the people having the RRSO surgery. However, the authors note that these findings were no longer statistically significant after 24 months.

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Research JAMA, Web page The URL will go live after the embargo ends

Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: The University of Melbourne, Moffitt Cancer Center, USA; University of Washington, USA

Funder: This study was funded by Stand Up To Cancer as part of the Ovarian Cancer Dream Team.

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