Expert Reaction

EXPERT REACTION: Smokers are more likely to quit cigarettes if they switch to vapes

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Australia; International; NSW; VIC
Photo by Romain B on Unsplash
Photo by Romain B on Unsplash

People who are trying to quit smoking tobacco are more likely to be successful if nicotine vapes are part of their strategy, according to international research. The team recruited 1,246 would-be quitters, and assigned 622 to receive free e-cigarettes, e-liquids and counselling. The other 624 received counselling and a voucher which could be used on whatever they wanted, including nicotine replacement therapy. Six months on, the researchers say 59.6% of the vaping group had not smoked a cigarette in the week before their check-up, compared to 38.5% of the group that did not use vapes.

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Expert Reaction

These comments have been collated by the Science Media Centre to provide a variety of expert perspectives on this issue. Feel free to use these quotes in your stories. Views expressed are the personal opinions of the experts named. They do not represent the views of the SMC or any other organisation unless specifically stated.

Associate Professor Michelle Jongenelis is Deputy Director and Principal Research Fellow at the Melbourne Centre for Behaviour Change, The University of Melbourne

While these research findings provide some promising evidence that nicotine e-cigarettes may assist smokers to quit, it is important to recognise that the study did not formally compare the use of e-cigarettes with other effective approaches to smoking cessation, such as nicotine replacement therapy or pharmacotherapy (e.g., varenicline, cytisine).

It is also important to note that those receiving nicotine e-cigarettes also received counselling. This is important as e-cigarettes are not approved as a smoking cessation device and have not been independently tested for quality, safety, and efficacy by the Therapeutic Goods Administration. They must be used under medical supervision so that your doctor can monitor any adverse effects and ensure the nicotine being delivered is appropriate.

It is critical that those who use e-cigarettes to quit smoking are then supported to quit the use of e-cigarettes. These products contain harmful chemicals and ongoing use is not recommended.

Last updated:  14 Feb 2024 11:27am
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Declared conflicts of interest None declared.

Dr Colin Mendelsohn is a retired academic, researcher, and smoking cessation clinician

This large (n=1246), well-conducted, open-label, randomised controlled trial found that e-cigarettes with nicotine combined with standard counselling were substantially more effective in helping motivated smokers to quit than standard counselling alone. After 6 months, 28.9% of smokers in the intervention group were continuously abstinent from the quit date compared to 16.3% in the control group (relative risk 1.77). The results are in line with those of the Cochrane review and support the use of vaping nicotine as an effective quit-smoking aid.

About half of the abstainers in the intervention group continued to vape at the end of the study. Continued vaping carries only a small fraction of the risk of smoking and can help to prevent relapse. Some continuing vapers will cease vaping over time. 

Importantly, vaping was well tolerated with no increase in severe adverse effects. Respiratory symptoms improved in the intervention group to a larger extent than for subjects in the control group.

The results support the findings from other research and suggest that vaping nicotine is an effective quitting aid with a good safety profile. Australian doctors should feel more confident in prescribing vaping products for their smoking patients, especially those unable to quit with other methods.

Last updated:  04 Mar 2024 11:55am
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Declared conflicts of interest Colin declares he has never personally received funding from e-cigarette or tobacco companies. He is the founding chairman of the Australian Tobacco Harm Reduction Association, which received seed funding from 2017-2019 from e-cigarette companies. He has received travel and accommodation expenses, but not speaker fees, from the organisers of a vaping and nicotine industry conference.

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Research Massachusetts Medical Society, Web page The URL will go live after the embargo ends
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conference:
New England Journal of Medicine
Research:Paper
Organisation/s: University of Bern, Switzerland
Funder: Funded by the Swiss National Science Foundation and others; ESTxENDS ClinicalTrials.gov number, NCT03589989.)
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