Media release
From:
The effect of body size and inbreeding on cancer mortality in breeds of the domestic dog: a test of the multistage model of carcinogenesis
Royal Society Open Science
Different breeds of dog have very different risks of cancer. It is shown that much of this variation can be explained by the interaction of large breed size increasing cancer risk with the opposite effect of size decreasing lifespan. The result is that large, but not the largest, breeds generally have the highest cancer risk. The details of this pattern provide insight into the number of genetic mutations that cause cancer in dogs, and were used to show that inbreeding in the ancestry of a breed shortens its lifespan, but in general does not increase cancer risk.
Contact: Dr Leonard Nunney, University of California Riverside, leonard.nunney@ucr.edu,