Reducing cholesterol in kids with high levels may help prevent heart disease later in life

Embargoed until: Publicly released: 2024-04-13 00:01

Australia; VIC

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Kids who have high levels of 'bad' cholesterol (non-high-density lipoprotein cholesterol) during childhood are at an increased risk of heart disease later in life, but Australian researchers have found that this risk is reduced if their cholesterol can be brought down to normal levels by the time they are adults. The authors say their findings suggest that interventions to prevent and reduce high cholesterol in childhood may help prevent premature cardiovascular disease.

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Journal/
conference: JAMA

Research:Paper

Organisation/s: Baker Heart and Diabetes Institute

Funder: This study was supported by NIH grant HL121230. DrMagnussen is supported by a National Health and Medical Research Council Investigator Grant (APP1176494). Historical funding sources for cohorts in the i3C Consortium are as follows: Bogalusa Heart Study: NIH grants SCOR-A/ P60 HL15103, U01 HL038844, R01 HL002942, R01 HD032194, R01 AG016592, R01 HD069587, R01 ES021724, R01 AG062309, R03 HD047247, R03 HD062783, R03 AG060619, R21/R33 AG057983, and RF1 AG041200 and American Heart Association grants 13SDG14650068 and 0160261B; Childhood Determinants of Adult Health Study: Commonwealth Department of Sport, Recreation and Tourism, Commonwealth Department of Health, Commonwealth Schools Commission, National Heart Foundation, National Health and Medical Research Council (grants 211316, 544923, 1128373), Tasmanian Community Fund, Veolia Environmental Services, and Mostyn Family Foundation; Minnesota Childhood Cardiovascular Cohorts: NIH grants R01 HL19877, R01 HL34659, R01 HL52851, R01 DK072124, and K23 HL04000, Vikings Children’s Fund, and a University of Minnesota Medical School Department of Pediatrics Legacy Grant; Muscatine Study: NIH grants SCOR HL14230 and SCOR HL44546, General Clinical Research Centers Program grants M01-FR59 and RR-00059, Lipid Research Clinics Program (grant NIH-NHLBI-N01-HV-2-2913-L), Juvenile Hypertension Program grant HL35600, NIH grants R01 HL20124, R01 HD13374, R01 HL48050, R01 HL54730, R01 HL61857 and R01 HD29569, Iowa Heart Association grants 74-G-28 and 75-G-76, Muscatine Rotary, Muscatine Health Support Foundation, and Roy J. Carver Charitable Trust. National Heart, Lung, and Blood Institute (NHLBI) Growth and Health Study: NIH grants N01-HC055025, U01 HL48941, R01 HL52911, R01 HL66430, and R21/R33 AG057983; Princeton Lipid Research Study: NIH NHLBI grants N01-HV022914L, R01 HL33973, R01 GM28719 HL62394, R21 DK085363, and R21/R33 AG057983 and American Heart Association grant 9750129N; Cardiovascular Risk in Young Finns Study: Academy of Finland grants 356405, 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi), Social Insurance Institution of Finland, Competitive State Research Financing of the Expert Responsibility Area of Kuopio, Tampere, and Turku University Hospitals (grant X51001), Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation for Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, Tampere Tuberculosis Foundation, Emil Aaltonen Foundation, Yrjö Jahnsson Foundation, Signe and Ane Gyllenberg Foundation, Diabetes Research Foundation of the Finnish Diabetes Association, EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition), European Research Council (grant 742927 for the MULTIEPIGEN Project), Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry, Cancer Foundation Finland, pBETTER4U_EU (project 101080117), and Jane and Aatos Erkko Foundation.

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