Premenstrual disorders linked to a higher risk of psychiatric disorders, and vice versa

Embargoed until: Publicly released: 2026-05-09 01:00

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Women with premenstrual disorders, including premenstrual syndrome (PMS), may be twice as likely to develop a psychiatric disorder, according to a large study of over 100,000 women in Sweden. The study found that the reverse was also true, and women with psychiatric disorders were at a higher risk of developing premenstrual disorders. The authors say this highlights the need for sex-specific and menstrual cycle–informed approaches in psychiatric assessment and care.

News release

From: JAMA

Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders

About The Study: In this nationwide cohort study conducted in Sweden, bidirectional associations were found between premenstrual disorders and psychiatric disorders and conditions, highlighting the need for sex- and menstrual cycle–informed care in psychiatry. Further research is needed to understand the underlying mechanisms shared between premenstrual disorders and psychiatric disorders.

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Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: Karolinska Institutet, Sweden

Funder: This study was funded by the Swedish Research Council for Health,Working Life andWelfare (FORTE) (2020-00971 and 2023-00399), the Swedish Research Council (2024-02592), the European Research Council (101165552), and the Karolinska Institutet Strategic Research Area in Epidemiology and Biostatistics, all to Dr Lu.

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