Post-shot side effects common - but serious reactions sparse

Embargoed until: Publicly released: 2021-12-23 03:00

International

Early ‘real world’ data from nearly 20,000 Americans suggests many people have mild post-vaccine adverse effects like fatigue or headache, but serious effects are scarce. People were more likely to experience negative effects after their second dose of a COVID-19 shot, with the Moderna vaccine, and if they were younger or female. This research also found a strong link between previous COVID-19 infection and adverse effects - including more severe. Allergic reaction or anaphylaxis was reported in just 0.2% of all participants after full vaccination.

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conference: JAMA Network Open

Research:Paper

Organisation/s: University of California - San Francisco, US

Funder: Conflict of Interest Disclosures: Dr Beatty reported being formerly employed by and holding stock in Apple, Inc, outside the submitted work. Dr Olgin reported receiving personal fees from Vivalnk and grants from Samsung outside the submitted work. Dr Pletcher reported receiving grants from the Patient-Centered Outcomes Research Institute, the National Institutes of Health (NIH), and the Bill and Melinda Gates Foundation during the conduct of the study. No other disclosures were reported. Funding/Support: The Eureka Research Platform is supported by grant 3U2CEB021881-05S1 from NIH/National Institute of Biomedical Imaging and Bioengineering to Drs Marcus, Olgin, and Pletcher. The COVID-19 Citizen Science Study is supported by Patient-Centered Outcomes Research Institute contract COVID-2020C2-10761 to Drs Pletcher, Marcus, and Olgin; the Bill and Melinda Gates Foundation contract INV-017206 to Drs Pletcher, Marcus, and Olgin, and grant 75N91020C00039 from NIH/National Cancer Institute to Drs Marcus, Hswen, Pletcher, and Olgin. Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

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