People with hard-to-treat schizophrenia have different gut bugs, and medication may be to blame

Embargoed until: Publicly released: 2024-02-01 03:00

Australia; QLD

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People with hard-to-treat, or treatment-resistant, schizophrenia have significantly different gut bugs making up their microbiome compared to people who respond well to treatment and those without the disorder, according to Australian research. The authors say the study suggests that medications may be driving the gut microbiome differences seen in schizophrenia.

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Journal/
conference: JAMA Psychiatry

Research:Paper

Organisation/s: The University of Queensland

Funder: The study was supported by Metro South Health Research Support Scheme grant RSS_2020_071.We also acknowledge funding from Princess Alexandra Hospital, National Health and Medical Research Council (investigator grant 2018431 to Dr Gratten and 1194635 to Prof Siskind), Queensland Centre for Mental Health, University of Queensland (Australian Research Training Program stipend and tuition fee offset and the Joan Lawrence Endowment prize for high-achieving women in neuroscience to Ms Vasileva) and the Mater Foundation (Drs Gratten and Yang).

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