International
International researchers suggest that having a genetic predisposition to higher levels of high-density lipoprotein cholesterol (commonly referred to as the 'good' cholesterol), and higher systolic blood pressure (the top measurement on a blood pressure reading) is associated with a higher risk of developing Alzheimer's disease (AD). The researchers used a technique called ‘Mendelian Randomisation’ - which uses genetics to allow scientists to determine whether one thing causes another, rather than them just being linked - on genetic data from over 39,000 people with AD and over 400,000 without.
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About The Study: This genetic association study including 39,000 participants with clinically diagnosed Alzheimer disease (AD) and 401,000 control participants without AD found novel genetic associations between high high-density lipoprotein (HDL) cholesterol concentrations and high systolic blood pressure with higher risk of AD. These findings may inspire new drug targeting and improved prevention implementation.
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