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This study aimed to explore Māori healthcare professionals’ current awareness, attitudes and perspectives on psychedelics and psychedelic-assisted therapy. Thirteen Māori healthcare professionals were recruited to participate in semi-structured qualitative interviews investigating psychedelic awareness, knowledge and attitudes using Māori health models Te Whare Tapa Whā and Te Wheke as a framework for data collection and analysis. Four key themes were identified as above. Our sample of Māori healthcare professionals generally supported research investigating psychedelic therapies in Aotearoa New Zealand. Improving awareness of this novel treatment is likely to influence its acceptability as a treatment option and will inform the cultural safety of its use with Māori.