International
The rates of leucovorin prescribing have soared in the US, with a 700% increase in one year and a huge jump after the Trump administration suggested leucovorin as a treatment for children with autism. In a press release issued in September 2025, the US Department of Health and Human Services stated it would authorise leucovorin (also known as folinic acid or calcium folinate) as treatment for children with autism spectrum disorder (ASD). The researchers say that while the data doesn't give the exact reasons for the prescriptions, it seems likely that there has been greater use for autism. They say this would be of concern, given that the efficacy and long-term safety of leucovorin for the treatment of autism is uncertain.
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