Ketamine-based drug reduces postpartum depression among women who've had a C-section

Embargoed until: Publicly released: 2025-02-14 03:00

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In a 'gold standard' clinical trial, Chinese scientists tested whether an infusion of esketamine - a more potent version of the drug ketamine - can reduce symptoms of postpartum depression (PPD) in women undergoing a Caesarean section. The trial included 308 women, around half of whom were given an esketamine infusion during their C-section, while the other half received an infusion of an inactive saline solution. Incidence of PPD was measured six weeks after the C-section, and the scientists found depression was less common among the women who'd received esketamine. In the esketamine group, 10% of women reported PPD, while in the saline group, 19% of women reported PPD. The findings suggest esketamine is safe and effective for reducing PPD following a C-section, the authors conclude.